EVALUATION OF MILLET STARCHES (Pennisetum glaucum and Pennisetum americanum) AS TABLET BINDERS AND DISINTEGRANTS
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- NGN 3000
Abstract
Starch was extracted from the two varieties of millet (Pennisetum glaucum and Pennisetum americanum) by the wet extraction method, the percentage yield was determined. The physicochemical properties investigated includes: flow rate, angle of repose, carr’s index, tapped density, bulk density, moisture content, swelling capacity, particle size, solubility, iodine test, and hausner ratio. Granules were prepared by the wet granulation method of massing and screening using the two varieties of millet starches as disintegrants and binders in one formulation and comparing their physicochemical properties with that of maize starch BP. Paracetamol tablets were formulated using Pennisetum glaucum and Pennisetum americanum starch as binder and disintegrant compared with maize starch and studying the tableting properties of the tablets produced. The percentage yields of starch from the two varieties of millet were found to be 50% for Pennisetum glaucum and 56.8% for Pennisetum americanum. The two starches have similar flow, swelling, power and moisture sorption properties. The suitability of millet starches as binders and disintegrants at various concentrations were investigated in tablet formulations using paracetamol as the medicinal substances. The millet starches (Pennisetum glaucum and Pennisetum americanum) formulations were compared for hardness, friability, disintegration time against maize starch formulations. Using the same concentrations of binders and disintegrants. The results indicated that millet starches were suitable binders and Disintegrants. When the disintegrant and binding properties were analysed and compared with maize starch There was an increase in tablet crushing strength as the disintegrant concentration xix increased. There was also a decrease in the friability of the tablets as binder concentration increased. Disintegration time was found to increase with increase in binder concentration.
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